Autofluorescencia de la Retina y su Utilidad Clínica
DOI:
https://doi.org/10.71413/13q58005Palabras clave:
Autofluorescencia de la Retina, Lipofuscina, ScreeningResumen
Relevancia: Técnica empleada para diagnosticar, monitorizar e investigar ciertas patologías retinianas. Cuya curva de aprendizaje es rápida, lo que cabe destacar que sea una técnica capaz de emplearse por ópticos-optometristas a modo de screening.
Resumen: Se analiza esta prueba de polo posterior, la cual se ha verificado su excelente capacidad diagnóstica para ciertas patologías que como factor común tienen el daño causado al epitelio pigmentario retiniano (EPR) y en multitud de ocasiones puede servir de alternativa a la angiografía fluoresceínica (AGF) y/o como complemento a otras medidas de polo posterior como la tomografía de coherencia óptica (OCT) o la retinografía a color, puesto que nos aporta información adicional.
Referencias
Mustonen E, Nieminen H. Optic disc drusen – a Photographic study. I. Autofluorescence pictures and fluorescein angiography. Acta Ophthalmol. 1982; 60:849–858 DOI: https://doi.org/10.1111/j.1755-3768.1982.tb00616.x
Neetens A, Burvenich H. Autofluorescence of optic disc-drusen. Bull Soc Belge Ophtalmol.1977; 179:103–110.
Schatz H, Burton TC, Yannuzzi LA, Rabb MF. Preinjection fluorescence. In. Mosby, St Louis; 1978.
Priel E. Fundus autofluorescence with a confocal scanning laser ophthalmoscope. J Ophthalmic Photo. 2007; 29:62–71.
Von Ruickmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995; 79:407–12. DOI: https://doi.org/10.1136/bjo.79.5.407
Spaide RF. Autofluorescence imaging with the fundus camera. In: Holz FG, Schmitz-Valckenberg S, Spaide RF, Bird AC, eds. Atlas of Fundus Autofluorescence Imaging. Berlin-Heidelberg: Springer- Verlag. 2007; 49–54.
Von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997; 38:478–486.
Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 2001; 42:1855–1866.
Sparrow JR, Dong Yoon K, Wu Y, Yamamoto K. Interpretations of Fundus Autofluorescence from Studies of the Bisretinoids of the Retina. Investigative Ophthalmology & Visual Science. Sept 2010; 51(9). DOI: https://doi.org/10.1167/iovs.10-5852
Delori FC, Keilhauer C, Sparrow JR, Staurenghi G. Origin of fundus autofluorescence. In: Holz FG, Schmitz-Valckenberg S, Spaide RF, Bird AC, eds. Atlas of Fundus Autofluorescence Imaging. Berlin- Heidelberg: Springer-Verlag; 2007: 17–29.
Del Priore LV, Kuo YH, Tezel TH. Age-related changes in human RPE cell density and apoptosis proportion in situ. Invest Ophthalmol Vis Sci. 2002; 43: 3312–3318.
Kim SR, Jang Y, Sparrow J.R. Photooxidation of RPE lipofuscina bisretinoids enhanced fluorescence intensity. Vision Res. 2010; 50: 729–736. DOI: https://doi.org/10.1016/j.visres.2009.09.015
Boulton M. Lipofuscin of the RPE. In: Lois N, Forrester JV, eds. Fundus Autofluorescence: Wolters Kluwer/Lippincott Williams and Wilkins. 2009; 14–26.
Boulton M, Rozanowska M, Rozanowski B, Wess T. The photoreactivity of ocular lipofuscin. Photochem Photobiol Sci. 2004; 3:759–764. DOI: https://doi.org/10.1039/b400108g
Travis GH, Golczak M, Moise AR, Palczewski K. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol. 2007; 47:469–512. DOI: https://doi.org/10.1146/annurev.pharmtox.47.120505.105225
Cuba J, Gómez-Ulla. Autofluorescencia retiniana: aplicaciones y perspectivas. Arch soc esp oftalmol. 2013; 88(2):50–55. DOI: https://doi.org/10.1016/j.oftal.2011.11.020
Eandi CM, Ober M, Iranmanesh R, Peiretti E, Yannuzzi LA. Acute central serous chorioretinopathy and fundus autofluorescence. Retina. 2005; 25:989–93. DOI: https://doi.org/10.1097/00006982-200512000-00006
Schmitz-Valckenberg S, Fleckenstein M, Spaide R, Holz FG. Medical retina: Autofluorescence Imaging. Berlin: Springer Berlin Heidelberg. 2010; 41-50. DOI: https://doi.org/10.1007/978-3-540-85540-8_5
Asli Dinc U, Tatlipinar S, Yenerel M, Görgün E, Ciftci F. Fundus autofluorescence in acute and chronic central serous chorioretinopathy. Clin Exp Optom. 2011; 94: 5: 452–457. DOI: https://doi.org/10.1111/j.1444-0938.2011.00598.x
Månsson M, Brautaset R., Walberg Ramsay M, Nilsson M. Fundus autofluorescence— with the Canon CR-2 PLUS. International Journal of Ophthalmic Practice, Octubre/Noviembre 2012; 3(5). DOI: https://doi.org/10.12968/ijop.2012.3.5.204
Holler FJ, Skoog DA, Crouch SR. Principles Of Instrumental Analysis; 2006.
Bearelly S, Cousins SW. Fundus Autofluorescence Imaging in Age-Related Macular Degeneration and Geographic Atrophy. Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology. 2010; 664:395-402. DOI: https://doi.org/10.1007/978-1-4419-1399-9_45
Morillo MJ, Mora J, Soler A, García-Campos JM, García-Fernández I,Sánchez P, Valdivieso P. Imágenes funduscópicas con autofluorescencia en pacientes con pseudoxantoma elástico. Archivos sociedad española de oftalmología. 2011; 86(1):8–15. DOI: https://doi.org/10.1016/j.oftal.2010.11.019
Fleckenstein M, Schmitz-Valckenberg S, Martens C, Kosanetzky S, Brinkmann CK, Hageman GS, Holz FG. Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Characteristics in a Rapidly Progressing Form of Geographic Atrophy. Invest Ophthalmol Vis Sci. Junio 2011; 52(6):3761-6. DOI: https://doi.org/10.1167/iovs.10-7021
Fleckenstein M, Schmitz-Valckenberg S, Martens C, Kosanetzky S, Brinkmann CK, Hageman GS, Holz FG. Diagnosis imaging in patients with retinitis pigmentosa. The Journal of medical investigation. 2012; vol 59.
Murakami T, Akimoto M, Ooto S, Suzuki T, Ikeda H, Kawagoe N, Takahashi M, Yoshimura N. Association between abnormal autofluorescence and photoreceptor disorganization in retinitis pigmentosa. Am J Ophthalmol. Abril 2008; 145(4):687-94. DOI: https://doi.org/10.1016/j.ajo.2007.11.018
Schmitz-Valckenberg S, Bültmann S, Dreyhaupt J, Bindewald A, Holz FG, Rohrschneider K. Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci. Diciembre 2004; 45(12):4470-6. DOI: https://doi.org/10.1167/iovs.03-1311
Scholl HP, Bellmann C, Dandekar SS et al. Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy. Invest Ophthalmol Vis Sci. 2004; 45:574–583. DOI: https://doi.org/10.1167/iovs.03-0495
Thampi P, Vittal Rao H, Mitter SK, Cai J, Mao H, Li H, Seo S, Qi X, Lewin AS, Romano C, Boulton ME. The 5HT1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium. PloS ONE. Abril 2012; 7. DOI: https://doi.org/10.1371/journal.pone.0034468
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Derechos de autor 2024 D. Alberto J. Villarroya Villanueva (Autor/a)
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
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