Retinal Autofluorescence and its Clinical Utility

Main Article Content

Alberto J. Villarroya Villanueva

Abstract

Relevance: Technique used to diagnose, monitor, and investigate certain retinal pathologies. Its learning curve is rapid, highlighting its suitability for use by optometrists as a screening tool.
Summary: This posterior pole test is analyzed, which has been verified for its excellent diagnostic capacity for certain pathologies characterized by damage to the retinal pigment epithelium (RPE). In many instances, it can serve as an alternative to fluorescein angiography (FA) and/or as a complement to other posterior pole measures such as optical coherence tomography (OCT) or color fundus photography, as it provides additional information.

Article Details

How to Cite
1.
Retinal Autofluorescence and its Clinical Utility. Optom Clin y Cienc Vis [Internet]. 2024 Feb. 2 [cited 2024 Sep. 19];1(4):3-11. Available from: https://revistaoccv.com/index.php/occv/article/view/14
Section
Systematic Reviews

How to Cite

1.
Retinal Autofluorescence and its Clinical Utility. Optom Clin y Cienc Vis [Internet]. 2024 Feb. 2 [cited 2024 Sep. 19];1(4):3-11. Available from: https://revistaoccv.com/index.php/occv/article/view/14

References

Mustonen E, Nieminen H. Optic disc drusen – a Photographic study. I. Autofluorescence pictures and fluorescein angiography. Acta Ophthalmol. 1982; 60:849–858

Neetens A, Burvenich H. Autofluorescence of optic disc-drusen. Bull Soc Belge Ophtalmol.1977; 179:103–110.

Schatz H, Burton TC, Yannuzzi LA, Rabb MF. Preinjection fluorescence. In. Mosby, St Louis; 1978.

Priel E. Fundus autofluorescence with a confocal scanning laser ophthalmoscope. J Ophthalmic Photo. 2007; 29:62–71.

Von Ruickmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995; 79:407–12.

Spaide RF. Autofluorescence imaging with the fundus camera. In: Holz FG, Schmitz-Valckenberg S, Spaide RF, Bird AC, eds. Atlas of Fundus Autofluorescence Imaging. Berlin-Heidelberg: Springer- Verlag. 2007; 49–54.

Von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997; 38:478–486.

Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 2001; 42:1855–1866.

Sparrow JR, Dong Yoon K, Wu Y, Yamamoto K. Interpretations of Fundus Autofluorescence from Studies of the Bisretinoids of the Retina. Investigative Ophthalmology & Visual Science. Sept 2010; 51(9).

Delori FC, Keilhauer C, Sparrow JR, Staurenghi G. Origin of fundus autofluorescence. In: Holz FG, Schmitz-Valckenberg S, Spaide RF, Bird AC, eds. Atlas of Fundus Autofluorescence Imaging. Berlin- Heidelberg: Springer-Verlag; 2007: 17–29.

Del Priore LV, Kuo YH, Tezel TH. Age-related changes in human RPE cell density and apoptosis proportion in situ. Invest Ophthalmol Vis Sci. 2002; 43: 3312–3318.

Kim SR, Jang Y, Sparrow J.R. Photooxidation of RPE lipofuscina bisretinoids enhanced fluorescence intensity. Vision Res. 2010; 50: 729–736.

Boulton M. Lipofuscin of the RPE. In: Lois N, Forrester JV, eds. Fundus Autofluorescence: Wolters Kluwer/Lippincott Williams and Wilkins. 2009; 14–26.

Boulton M, Rozanowska M, Rozanowski B, Wess T. The photoreactivity of ocular lipofuscin. Photochem Photobiol Sci. 2004; 3:759–764.

Travis GH, Golczak M, Moise AR, Palczewski K. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol. 2007; 47:469–512.

Cuba J, Gómez-Ulla. Autofluorescencia retiniana: aplicaciones y perspectivas. Arch soc esp oftalmol. 2013; 88(2):50–55.

Eandi CM, Ober M, Iranmanesh R, Peiretti E, Yannuzzi LA. Acute central serous chorioretinopathy and fundus autofluorescence. Retina. 2005; 25:989–93.

Schmitz-Valckenberg S, Fleckenstein M, Spaide R, Holz FG. Medical retina: Autofluorescence Imaging. Berlin: Springer Berlin Heidelberg. 2010; 41-50.

Asli Dinc U, Tatlipinar S, Yenerel M, Görgün E, Ciftci F. Fundus autofluorescence in acute and chronic central serous chorioretinopathy. Clin Exp Optom. 2011; 94: 5: 452–457.

Månsson M, Brautaset R., Walberg Ramsay M, Nilsson M. Fundus autofluorescence— with the Canon CR-2 PLUS. International Journal of Ophthalmic Practice, Octubre/Noviembre 2012; 3(5).

Holler FJ, Skoog DA, Crouch SR. Principles Of Instrumental Analysis; 2006.

Bearelly S, Cousins SW. Fundus Autofluorescence Imaging in Age-Related Macular Degeneration and Geographic Atrophy. Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology. 2010; 664:395-402.

Morillo MJ, Mora J, Soler A, García-Campos JM, García-Fernández I,Sánchez P, Valdivieso P. Imágenes funduscópicas con autofluorescencia en pacientes con pseudoxantoma elástico. Archivos sociedad española de oftalmología. 2011; 86(1):8–15.

Fleckenstein M, Schmitz-Valckenberg S, Martens C, Kosanetzky S, Brinkmann CK, Hageman GS, Holz FG. Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Characteristics in a Rapidly Progressing Form of Geographic Atrophy. Invest Ophthalmol Vis Sci. Junio 2011; 52(6):3761-6.

Fleckenstein M, Schmitz-Valckenberg S, Martens C, Kosanetzky S, Brinkmann CK, Hageman GS, Holz FG. Diagnosis imaging in patients with retinitis pigmentosa. The Journal of medical investigation. 2012; vol 59.

Murakami T, Akimoto M, Ooto S, Suzuki T, Ikeda H, Kawagoe N, Takahashi M, Yoshimura N. Association between abnormal autofluorescence and photoreceptor disorganization in retinitis pigmentosa. Am J Ophthalmol. Abril 2008; 145(4):687-94.

Schmitz-Valckenberg S, Bültmann S, Dreyhaupt J, Bindewald A, Holz FG, Rohrschneider K. Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci. Diciembre 2004; 45(12):4470-6.

Scholl HP, Bellmann C, Dandekar SS et al. Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy. Invest Ophthalmol Vis Sci. 2004; 45:574–583.

Thampi P, Vittal Rao H, Mitter SK, Cai J, Mao H, Li H, Seo S, Qi X, Lewin AS, Romano C, Boulton ME. The 5HT1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium. PloS ONE. Abril 2012; 7.

Similar Articles

You may also start an advanced similarity search for this article.